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わたしの備忘録、生物学とプログラミングが多いかも

曲がる歩行運動/カーブの運動

将来の論文

Identification of “steering” neuron
and
prediction of “sterring” movement

Human walking along a curved path. II. Gait features and EMG patterns

Grégoire Courtine and Marco Schieppati

Article first published online: 11 JUL 2003

DOI: 10.1046/j.1460-9568.2003.02737.x

ゼブラフィッシュ

www.ncbi.nlm.nih.gov

 曲がる、に関する言葉

curved-path
steering
bend turning
lateral turning responses

#

Mind the bend: cerebral activations associated with mental imagery of walking along a curved path | SpringerLink

全身のEMG

Coordinated modulation of locomotor muscle synergies constructs straight-ahead and curvilinear walking in humans | SpringerLink

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How do humans turn? Head and body movements for the steering of locomotion Halim Hicheur and Alain Berthoz - IEEE Xplore Document

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How Do We Control High Speed Steering? - Springer

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http://www.sciencedirect.com/science/article/pii/0165017388900082
過去の知見として、色々な脳部位の刺激が、目と頭の横動き、それに続く体の曲がりと円運動

Grillner(2003)のreviewより

Steering and body orientation
… Such asymmetric reticulospinal activation occurs during left–right turning in the lamprey.
The motor infrastructure: from ion channels to neuronal networks. - PubMed - NCBI

  • .74. Matsushima, T. & Grillner, S. Neural mechanisms of intersegmental coordination in lamprey: local excitability changes modify the phase coupling along the spinal cord. J. Neurophysiol. 67, 373–88 (1992).
  • .116. Fagerstedt, P. & Ullen, F. Lateral turns in the lamprey. I. Patterns of motoneuron activity. J. Neurophysiol. 86, 2246–2256 (2001).
  • .117. Deliagina, T. G., Zelenin, P. V., Fagerstedt, P., Grillner, S. & Orlovsky, G. N. Activity of reticulospinal neurons during locomotion in the freely behaving lamprey. J. Neurophysiol. 83, 853–863 (2000).

117. Activity of reticulospinal neurons during locomotion in the freely behaving lamprey.(2000)

http://m.jn.physiology.org/content/83/2/853.long?view=long&pmid=10669499#F7

わかっていたこと:

わかっていなかったこと:

  • in vivo(様々なmodalityの入力下)におけるRS cellsの活動

方法:

  • model: lamprey(free moving)
  • macroelectorode(板電極)によるRS cellsのpopulation activity測定

わかったこと:

  • Unilateral刺激でもbilateralにRSが応答

残った課題:

steeringに関わるところ

http://m.jn.physiology.org/content/83/2/853/F7.large.jpg
ipsi-RSが優位に応答(?)

  • preのbaseがそもそも違う
  • turnとswimの両方に聞いてる可能性とその解釈
  • macroelectrodeによるfilteringでローカルの処理を排除できているのか

Two lines of evidence support this suggestion. First, the symmetry of motor output during fictive swimming generated by the spinal cord can be strongly affected by stimulation of a single RS neuron (Buchanan and Cohen 1982). Second, a small asymmetry in the mass activity of the left and right RS pathways, caused by electrical stimulation, can result in a generation of a pure unilateral motor output (Zelenin et al. 1997). In both cases, the “amplification” of the asymmetry occurred in the spinal cord, and it is most likely based on the operation of the system of reciprocal inhibition between the two hemi-segments (Cohen and Harris-Warrick 1984; Grillner and Wallén 1980; Wallén et al. 1993).

Buchanan and Cohen, 1982

www.ncbi.nlm.nih.gov

lateral turn in the lumprey. 1. 2001.

http://m.jn.physiology.org/content/86/5/2246.full

McClellan et al. JN Physiol ,1997.

Descending Control of Turning Locomotor Activity in Larval Lamprey: Neurophysiology and Computer Modeling.
http://m.jn.physiology.org/content/78/1/214.long?view=long&pmid=9242275
model: larval lamprey

前提として挙げていること:

  • spinal cordの運動回路は3要素
    • CPG
    • inter-segment corrdinator
    • MNs
  • MNsはCPGに含まれない

したこと:

  • spontanious turningの行動評価
  • fictive turningの電気生理
  • シミュレーション

気になる部分

In fish, locomotor behavior consists of two main features: right-left bending of the body at a given segmental level and body undulations that propagate toward the tail (Grillner and Kashin 1976).

Turning maneuvers are produced by an initial larger-than-normal bending of the head to one side (Gray 1933).

Thirle et al. Neuron. 2014.

[http://www.sciencedirect.com/science/article/pii/S0896627314003328?rdoc=1&fmt=high&origin=gateway&docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffb:title]

わかっていたこと

  • nMLFが様々な行動に関わっていること

わかっていなかったこと

  • nMLFの役割

実験手法

  • model: zebrafish
  • methods:

#

Gray J (1933b) Directional control of fish movement. Proc R Soc Lond B Biol Sci 113:115–125.

steeringとは違うけれども

www.ncbi.nlm.nih.gov